Perfluorohexanoic Acid (PFHxA, C-6)CAS 307-24-4
Intermediate-chain 'GenX-era' PFAS — half-life weeks rather than years, but still persistent.
Toxic Chemical Databases
Substance-specific listings — these flags are for Perfluorohexanoic Acid alone, not for the broader family.
Chemical Type
Medium-Chain C6 Perfluoroalkyl Carboxylic Acid
Chemical Description
PFHxA is the six-carbon perfluoroalkyl carboxylic acid — intermediate between PFOA and PFBA. Human serum half-life is roughly 1-2 months — lower than PFOA but much higher than the 4-carbon analog. Used as a replacement for PFOA in stain-resistant treatments and specialty coatings. EU added PFHxA-and-salts to the REACH SVHC Candidate List in 2024 for persistence and mobility.
Biological Activity
Severity scores specific to this substance, NOT the parent family average. Differences between siblings are real and meaningful.
Top Health Consequences
- Liver enzyme induction and altered lipid metabolism
- Thyroid effects in developmental studies
- REACH SVHC — persistence, mobility, and bioaccumulation concerns
- Increasing drinking-water concentrations globally
Pathways of Exposure
- Drinking water contamination from manufacturing sites
- Diet — accumulation in crops irrigated with contaminated water
- Inhalation of fluoropolymer degradation products
Building Materials with Perfluorohexanoic Acid
Listed alphabetically — product categories where this specific substance appears.
Replacement Stain-Resistant Treatments
Specialty Architectural Coatings