Upload a manufacturer’s SDS PDF — auto-scan CAS numbers against LBC Red List, Prop 65, IARC, NTP RoC, NIOSH, GSPI Six Classes of Concern, plus VOC & SVOC classification
| Column | Code | Meaning |
|---|---|---|
| Prop 65 Toxicity | C | Carcinogen |
| D | Developmental toxicity | |
| M | Male reproductive toxicity | |
| F | Female reproductive toxicity | |
| C,D,M,F | All four (e.g., DEHP) | |
| IARC Group | 1 | Carcinogenic to humans |
| 2A | Probably carcinogenic | |
| 2B | Possibly carcinogenic | |
| 3 | Not classifiable | |
| NTP RoC Status | known | Known human carcinogen |
| ra | Reasonably anticipated to be a human carcinogen | |
| NIOSH Listed | yes | Has NIOSH Pocket Guide entry (PEL/REL/IDLH/symptoms shown in the tool) |
Every CAS Registry Number extracted from Section 3 of the uploaded SDS is matched (with check-digit validation, plus normalization variants) against an embedded local copy of each screening database. If the CAS appears verbatim on a given list, the bubble for that database turns RED (POSITIVE) and shows the listing’s specific classification (e.g. "Group 1", "Cancer + Develop.", "Known carcinogen", "PEL / REL listed"). If the CAS is not on the list, the bubble turns GREEN (CLEAR). The screener does not infer or extrapolate toxicity — it only reports verbatim membership in the curated authoritative lists, so a CLEAR bubble means "not on this specific list" and not "safe."
Source-list snapshots: LBC Red List CASRN Guide (Feb 2025) · Prop 65 (CDPH/OEHHA, current snapshot) · IARC Monographs (vols. 1–134) · NTP Report on Carcinogens (15th Report, Dec 2021) · NIOSH Pocket Guide (2019 ed.). Authoritative lists are updated periodically; for absolute-current listings, consult the source authority directly.
For each chemical with a curated profile, the Top Health Consequences bars summarize the best-evidenced organ-system effects from a literature review of the sources above. The Biochemical Mechanism of Action box describes the molecular-level mechanism (covalent modification, receptor binding, DNA adduct formation, oxidative stress, enzyme inhibition, etc.) as established in primary research. The Body-System Risk Summary grid restates the bar data as a quick-glance card per affected organ system.
Severity scores (0–10) are an editorial synthesis of the consensus weight-of-evidence in the sources above. They are intended for screening and education — not as a substitute for exposure modeling, regulatory exposure limits, or consultation with a qualified toxicologist or industrial-hygiene professional.
Class-level (group) profiles are used when no chemical-specific profile is available for a CAS; they describe hazards typical of the chemical family (phthalates, PFAS, chlorinated solvents, organophosphate flame retardants, etc.) drawn from the same source authorities.
A voluntary green-building standard listing chemicals identified as harmful to industry workers, ecosystems, or building occupants. Three tiers: Red List (avoid entirely), Priority Red List (pending inclusion), Watch List (potential health concerns under review). Listings are based on peer-reviewed evidence of carcinogenicity, endocrine disruption, persistence, bioaccumulation, and exposure pathways in the built environment.
GHS is the United Nations' globally adopted framework for classifying chemical hazards — every authoritative regulator (OSHA, REACH, WHMIS, JIS, etc.) maps onto it. Every SDS in the world references GHS H-codes (H225, H319, H350…) in its Section 2 hazard table.
PubChem aggregates GHS classifications submitted by hundreds of data sources (manufacturers, regulators, peer-reviewed safety reports). At screening time we retrieve the consensus classification for each CAS Registry Number live from the PubChem REST API. The bubble below the database name reflects the verdict in one of five states:
Common H-codes you’ll see in DANGER results: H225 "Highly flammable liquid and vapor", H300/301/311/331 acute toxicity (oral/dermal/inhalation), H304 "May be fatal if swallowed and enters airways" (aspiration hazard for hydrocarbons), H314 "Causes severe skin burns and eye damage", H334 "May cause allergy or asthma symptoms if inhaled" (isocyanate sensitization), H335 "May cause respiratory irritation", H340/341 mutagenicity, H350/351 carcinogenicity, H360/361 reproductive toxicity, H370/371/372/373 specific target-organ toxicity, H400/410/411 aquatic toxicity.
Data freshness: Results are cached in your browser for 30 days per CAS to avoid hammering the PubChem API on every upload. Cache key is bumped whenever the parser or rating logic changes, so stale entries from earlier tool versions are automatically discarded on first load. All lookups happen client-side from your browser to PubChem — no CAS numbers ever leave your machine via this tool’s servers (there are none).
A list of chemicals "known to the State of California to cause cancer, birth defects, or other reproductive harm." Substances are listed when authoritative bodies (IARC, NTP, US EPA, US FDA) classify them as carcinogens, developmental toxicants, or reproductive toxicants. Toxicity codes: C = Cancer, D = Developmental, M = Male reproductive, F = Female reproductive.
Evaluates evidence of carcinogenicity to humans based on human, animal, and mechanistic studies. Classifies into Group 1 (carcinogenic to humans), Group 2A (probably carcinogenic), Group 2B (possibly carcinogenic), or Group 3 (not classifiable as to carcinogenicity in humans). Each classification is supported by a published Monograph reviewing the entire weight of evidence.
A congressionally mandated public-health document identifying substances that are known to be human carcinogens or are reasonably anticipated to be human carcinogens, based on substantial human or animal evidence and supporting mechanistic data. Listings are reviewed by an inter-agency federal scientific panel.
A workplace-hazard reference for chemicals with established occupational exposure limits. Provides the NIOSH REL (Recommended Exposure Limit), OSHA PEL (Permissible Exposure Limit), IDLH concentration (Immediately Dangerous to Life or Health), target organs, exposure symptoms, and a skin-absorption (SKIN) flag.
Per WHO indoor-air classification, VOCs have boiling points of roughly 50–250°C (vapor pressure ≥ 0.13 kPa at 25°C). The US EPA defines VOCs as organic compounds participating in atmospheric photochemical reactions (40 CFR 51.100(s), with regulatory exemptions for some compounds).
Per WHO classification, SVOCs have boiling points of ~250–380°C (vapor pressure 10⁻⁹ to 10⁻² kPa). Unlike VOCs, they persist in indoor dust and on surfaces and remain a major source of long-term exposure long after a building product is installed.